High concordance of protein (by IHC), gene (by FISH; HER2 only), and microarray readout (by TargetPrint) of ER, PgR, and HER2: results from the EORTC 10041/BIG 03-04 MINDACT trial.

ABSTRACT:

Background

To investigate the correlation of TargetPrint with local and central immunohistochemistry/fluorescence in situ hybridization assessment of estrogen (ER), progesterone (PgR), and human epidermal growth factor receptor 2 (HER2) in the first 800 patients enrolled in the MINDACT trial.

Patients and methods

Data from local (N = 800) and central (N = 626) assessments of receptor status were collected and compared with TargetPrint results.

Results

For ER, the positive agreement (the percentage of central pathology positive assessments that were also TargetPrint/local laboratory positive) for TargetPrint in comparison to centralized assessment was 98% with a negative agreement (the percentage of central pathology negative assessments that were also TargetPrint/loca

SUBMITTER: Viale G 

PROVIDER: S-EPMC3969556 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature