Emergence and evolutionary analysis of the human DDR network: implications in comparative genomics and downstream analyses.

ABSTRACT: The DNA damage response (DDR) is a crucial signaling network that preserves the integrity of the genome. This network is an ensemble of distinct but often overlapping subnetworks, where different components fulfill distinct functions in precise spatial and temporal scenarios. To understand how these elements have been assembled together in humans, we performed comparative genomic analyses in 47 selected species to trace back their emergence using systematic phylogenetic analyses and estimated gene ages. The emergence of the contribution of posttranslational modifications to the complex regulation of DDR was also investigated. This is the first time a systematic analysis has focused on the evolution of DDR subnetworks as a whole. Our results indicate that a DDR core, mostly constructed arou

SUBMITTER: Arcas A 

PROVIDER: S-EPMC3969565 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature