The relation between recombination rate and patterns of molecular evolution and variation in Drosophila melanogaster.

ABSTRACT: Genetic recombination associated with sexual reproduction increases the efficiency of natural selection by reducing the strength of Hill-Robertson interference. Such interference can be caused either by selective sweeps of positively selected alleles or by background selection (BGS) against deleterious mutations. Its consequences can be studied by comparing patterns of molecular evolution and variation in genomic regions with different rates of crossing over. We carried out a comprehensive study of the benefits of recombination in Drosophila melanogaster, both by contrasting five independent genomic regions that lack crossing over with the rest of the genome and by comparing regions with different rates of crossing over, using data on DNA sequence polymorphisms from an African population t

SUBMITTER: Campos JL 

PROVIDER: S-EPMC3969569 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature