Using zebrafish models to explore genetic and epigenetic impacts on evolutionary developmental origins of aging.

ABSTRACT: Can we reset, reprogram, rejuvenate, or reverse the organismal aging process? Certain genetic manipulations could at least reset and reprogram epigenetic dynamics beyond phenotypic plasticity and elasticity in cells, which can be manipulated further into organisms. However, in a whole complex aging organism, how can we rejuvenate intrinsic resources and infrastructures in an intact and noninvasive manner? The incidence of diseases increases exponentially with age, accompanied by progressive deteriorations of physiological functions in organisms. Aging-associated diseases are sporadic but essentially inevitable complications arising from senescence. Senescence is often considered the antithesis of early development, but yet there may be factors and mechanisms in common between these 2 pheno

SUBMITTER: Kishi S 

PROVIDER: S-EPMC3969878 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature