Stretchable, multiplexed pH sensors with demonstrations on rabbit and human hearts undergoing ischemia.

ABSTRACT: Stable pH is an established biomarker of health, relevant to all tissues of the body, including the heart. Clinical monitoring of pH in a practical manner, with high spatiotemporal resolution, is particularly difficult in organs such as the heart due to its soft mechanics, curvilinear geometry, heterogeneous surfaces, and continuous, complex rhythmic motion. The results presented here illustrate that advanced strategies in materials assembly and electrochemical growth can yield interconnected arrays of miniaturized IrOx pH sensors encapsulated in thin, low-modulus elastomers to yield conformal monitoring systems capable of noninvasive measurements on the surface of the beating heart. A thirty channel custom data acquisition system enables spatiotemporal pH mapping with a single potentiosta

SUBMITTER: Chung HJ 

PROVIDER: S-EPMC3969880 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature