Myocardial infarction risk among patients with fractures receiving bisphosphonates.

ABSTRACT:

Objective

To determine if bisphosphonates are associated with reduced risk of acute myocardial infarction (AMI).

Patients and methods

A cohort of 14,256 veterans 65 years or older with femoral or vertebral fractures was selected from national administrative databases operated by the US Department of Veterans Affairs and was derived from encounters at Veterans Affairs facilities between October 1, 1998, and September 30, 2006. The time to first AMI was assessed in relationship to bisphosphonate exposure as determined by records from the Pharmacy Benefits Management Database. Time to event analysis was performed using multivariate Cox proportional hazards regression. An adjusted survival analysis curve and a Kaplan-Meier survival curve were analyzed.

Results

After contr

SUBMITTER: Pittman CB 

PROVIDER: S-EPMC3970112 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature