Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children.

ABSTRACT:

Background

Recovery from a massive burn is characterized by catabolic and hypermetabolic responses that persist up to 2 years and impair rehabilitation and reintegration. The objective of this study was to determine the effects of long-term treatment with recombinant human growth hormone (rhGH) on growth, hypermetabolism, body composition, bone metabolism, cardiac work, and scarring in a large prospective randomized single-center controlled clinical trial in pediatric patients with massive burns.

Patients and methods

A total of 205 pediatric patients with massive burns over 40% total body surface area were prospectively enrolled between 1998 and 2007 (clinicaltrials.gov ID NCT00675714). Patients were randomized to receive either placebo (n = 94) or long-term rhGH at 0.05, 0.

SUBMITTER: Branski LK 

PROVIDER: S-EPMC3970433 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature