Water diffusion reveals networks that modulate multiregional morphological plasticity after repetitive brain stimulation.

ABSTRACT: Repetitive brain stimulation protocols induce plasticity in the stimulated site in brain slice models. Recent evidence from network models has indicated that additional plasticity-related changes occur in nonstimulated remote regions. Despite increasing use of brain stimulation protocols in experimental and clinical settings, the neural substrates underlying the additional effects in remote regions are unknown. Diffusion-weighted MRI (DWI) probes water diffusion and can be used to estimate morphological changes in cortical tissue that occur with the induction of plasticity. Using DWI techniques, we estimated morphological changes induced by application of repetitive transcranial magnetic stimulation (rTMS) over the left primary motor cortex (M1). We found that rTMS altered water diffusion

SUBMITTER: Abe M 

PROVIDER: S-EPMC3970501 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature