Diversity and evolution of secondary metabolism in the marine actinomycete genus Salinispora.

ABSTRACT: Access to genome sequence data has challenged traditional natural product discovery paradigms by revealing that the products of most bacterial biosynthetic pathways have yet to be discovered. Despite the insight afforded by this technology, little is known about the diversity and distributions of natural product biosynthetic pathways among bacteria and how they evolve to generate structural diversity. Here we analyze genome sequence data derived from 75 strains of the marine actinomycete genus Salinispora for pathways associated with polyketide and nonribosomal peptide biosynthesis, the products of which account for some of today's most important medicines. The results reveal high levels of diversity, with a total of 124 pathways identified and 229 predicted with continued sequencing. Rece

SUBMITTER: Ziemert N 

PROVIDER: S-EPMC3970525 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature