The role of polymorphisms associated with early tooth eruption in dental and occlusal traits in East Asian populations.

ABSTRACT:

Objective

A recent study suggested that rs6504340, a polymorphism within the homeobox B (HOXB) gene cluster, is associated with the susceptibility for malocclusions in Europeans. The resulting malocclusions require orthodontic treatment. The aim of this study was to investigate the association of rs6504340 and other dentition-implicated polymorphisms with dental and occlusal traits in Korean and Japanese populations.

Methods

The study participants included 223 unrelated Koreans from the Busan area and 256 unrelated Japanese individuals from the Tokyo metropolitan area. DNA samples were extracted from saliva specimens. Genotyping for rs6504340 and four single nucleotide polymorphisms (SNPs) that have been shown to be associated with the timing of first tooth eruption and the

SUBMITTER: Yamaguchi T 

PROVIDER: S-EPMC3971131 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature