Cellular reactions to biodegradable magnesium alloys on human growth plate chondrocytes and osteoblasts.

ABSTRACT:

Purpose

In recent decades operative fracture treatment using elastic stable intramedullary nails (ESINs) has mainly taken precedence over conservative alternatives in children. The development of biodegradable materials that could be used for ESINs would be a further step towards treatment improvement. Due to its mechanical and elastic properties, magnesium seems to be an ideal material for biodegradable implant application. The aim of this study was therefore to investigate the cellular reaction to biodegradable magnesium implants in vitro.

Methods

Primary human growth plate chondrocytes and MG63 osteoblasts were used for this study. Viability and metabolic activity in response to the eluate of a rapidly and a slower degrading magnesium alloy were investigated. Furthermore,

SUBMITTER: Pichler K 

PROVIDER: S-EPMC3971266 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature