Effect of depression and sertraline treatment on cardiac function in female nonhuman primates.

ABSTRACT:

Objective

Depression is a proposed risk factor for heart failure based largely on epidemiological data; few experimental data addressing this hypothesis are available.

Methods

Depression was evaluated in relation to cardiac structural and functional phenotypes assessed by transthoracic echocardiography in 42 adult female cynomolgus monkeys that consumed a Western-like diet for 3 years. Half of the monkeys were treated with sertraline HCl for 18 months, and depressive behavior was assessed for 12 months before echocardiography.

Results

Depressed monkeys (the 19/42 with depressive behavior rates above the mean rate) had higher heart rates (HRs; 171 [4.1[ versus 152 [6.1]) and smaller body surface area (0.13 [0.003] versus 0.15 [0.004]), left ventricular (LV) end-systoli

SUBMITTER: Groban L 

PROVIDER: S-EPMC3971435 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature