Chromosome 10, frequently lost in human melanoma, encodes multiple tumor-suppressive functions.

ABSTRACT: Although many DNA aberrations in melanoma have been well characterized, including focal amplification and deletions of oncogenes and tumor suppressors, broad regions of chromosomal gain and loss are less well understood. One possibility is that these broad events are a consequence of collateral damage from targeting single loci. Another possibility is that the loss of large regions permits the simultaneous repression of multiple tumor suppressors by broadly decreasing the resident gene dosage and expression. Here, we test this hypothesis in a targeted fashion using RNA interference to suppress multiple candidate residents in broad regions of loss. We find that loss of chromosome regions 6q, 10, and 11q21-ter is correlated with broadly decreased expression of most resident genes and that mu

SUBMITTER: Kwong LN 

PROVIDER: S-EPMC3971520 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature