Co-occurrence of anaerobic bacteria in colorectal carcinomas.

ABSTRACT:

Background

Numerous cancers have been linked to microorganisms. Given that colorectal cancer is a leading cause of cancer deaths and the colon is continuously exposed to a high diversity of microbes, the relationship between gut mucosal microbiome and colorectal cancer needs to be explored. Metagenomic studies have shown an association between Fusobacterium species and colorectal carcinoma. Here, we have extended these studies with deeper sequencing of a much larger number (n = 130) of colorectal carcinoma and matched normal control tissues. We analyzed these data using co-occurrence networks in order to identify microbe-microbe and host-microbe associations specific to tumors.

Results

We confirmed tumor over-representation of Fusobacterium species and observed significant c

SUBMITTER: Warren RL 

PROVIDER: S-EPMC3971631 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature