Randomized trial to evaluate nutritional status and absorption of enteral feeding after brain death.

ABSTRACT:

Context

Catecholamines and inflammatory mediators, with elevated levels after brain death, are associated with reduced function and survival of transplanted organs. Enteral nutrition reduces tissue damage and may benefit organs.

Objective

To evaluate the effects of immunomodulating enteral nutrition in organ donors.

Design

Prospective, randomized, open-label study.

Setting

Intensive care unit.

Patients

Thirty-six brain-dead organ donors.

Interventions

Donors were randomized to receive enteral nutrition containing omega-3 polyunsaturated fatty acid, antioxidants, and glutamine or standard care (fasting). Donors received hormonal replacement therapy of corticosteroid, levothyroxine, dextrose, and insulin.

Main outcome measures

Gastrointestina

SUBMITTER: Hergenroeder GW 

PROVIDER: S-EPMC3971639 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature