Circulating fetuin-A and risk of ischemic stroke in women.

ABSTRACT:

Background

Fetuin-A, a protein secreted primarily by the liver, has been associated with nonalcoholic fatty liver disease and insulin resistance. In a recent study, higher circulating fetuin-A was associated with cardiovascular events, particularly ischemic stroke. However, these data have not been replicated.

Methods

A nested case control design was used to examine the relationship between fetuin-A and ischemic stroke among female participants of the Nurses' Health Study. Fetuin-A was measured in blood samples collected and stored between 1989 and 1990. A total of 459 incident cases of ischemic stroke were identified and confirmed by medical records according to the National Survey of Stroke criteria between 1990 and 2006 and matched to 459 controls by age, race/ethnicity,

SUBMITTER: Jimenez MC 

PROVIDER: S-EPMC3971644 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature