Pilot study demonstrating potential association between breast cancer image-based risk phenotypes and genomic biomarkers.

ABSTRACT:

Purpose

In this pilot study, the authors examined associations between image-based phenotypes and genomic biomarkers. The potential genetic contribution of UGT2B genes to interindividual variation in breast density and mammographic parenchymal patterns is demonstrated by performing an association study between image-based phenotypes and genomic biomarkers [single-nucleotide polymorphism (SNP) genotypes].

Methods

This candidate-gene approach study included 179 subjects for whom both mammograms and blood DNA samples had been obtained. The full-field digital mammograms were acquired using a GE Senographe 2000D FFDM system (12-bit; 0.1 mm-pixel size). Regions-of-interest, 256 × 256 pixels in size, selected from the central breast region behind the nipple underwent computerized i

SUBMITTER: Li H 

PROVIDER: S-EPMC3971831 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature