ABO blood type A is associated with increased risk of ARDS in whites following both major trauma and severe sepsis.

ABSTRACT:

Background

ABO glycosyltransferases catalyze antigen modifications on various glycans and glycoproteins and determine the ABO blood types. Blood type A has been associated with increased risk of vascular diseases and differential circulating levels of proteins related to inflammation and endothelial function. The objective of this study was to determine the association of ABO blood types with ARDS risk in patients with major trauma and severe sepsis.

Methods

We conducted prospective cohort studies in two populations at an urban tertiary referral, level I trauma center. Critically ill patients (n 5 732) presenting after major trauma were followed for 5 days for ARDS development. Additionally, 976 medical patients with severe sepsis were followed for 5 days for ARDS. Multivari

SUBMITTER: Reilly JP 

PROVIDER: S-EPMC3971970 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature