A shrinkage method for testing the Hardy-Weinberg equilibrium in case-control studies.

ABSTRACT: Testing for the Hardy-Weinberg equilibrium (HWE) is often used as an initial step for checking the quality of genotyping. When testing the HWE for case-control data, the impact of a potential genetic association between the marker and the disease must be controlled for otherwise the results may be biased. Li and Li [2008] proposed a likelihood ratio test (LRT) that accounts for this potential genetic association and it is more powerful than the commonly used control-only χ² test. However, the LRT is not efficient when the marker is independent of the disease, and also requires numerical optimization to calculate the test statistic. In this article, we propose a novel shrinkage test for assessing the HWE. The proposed shrinkage test yields higher statistical power than the LRT when the mark

SUBMITTER: Zang Y 

PROVIDER: S-EPMC3972031 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature