Disruption of canonical TGFβ-signaling in murine coronary progenitor cells by low level arsenic.

ABSTRACT: Exposure to arsenic results in several types of cancers as well as heart disease. A major contributor to ischemic heart pathologies is coronary artery disease, however the influences by environmental arsenic in this disease process are not known. Similarly, the impact of toxicants on blood vessel formation and function during development has not been studied. During embryogenesis, the epicardium undergoes proliferation, migration, and differentiation into several cardiac cell types including smooth muscle cells which contribute to the coronary vessels. The TGFβ family of ligands and receptors is essential for developmental cardiac epithelial to mesenchymal transition (EMT) and differentiation into coronary smooth muscle cells. In this in vitro study, 18hour exposure to 1.34μM arsenite disr

SUBMITTER: Allison P 

PROVIDER: S-EPMC3972124 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature