Effects of equol on gene expression in female cynomolgus monkey iliac arteries.

ABSTRACT:

Background and aims

To examine effects of equol, the soy phytoestrogen metabolite, on gene expression in the monkey iliac artery.

Methods and results

A high fat/high cholesterol diet was fed to eight ovariectomized cynomolgus monkeys for 6.5 years. After biopsy of the left iliac artery, the animals were randomized to two treatment groups for 8 months; the treatment groups were equol (23.7 mg/100 g diet, n = 4) and vehicle (n = 4). The right iliac artery was removed at necropsy. Gene expression in the iliac arteries in response to equol was determined by DNA microarray. Comparison of atherosclerotic lesions and plasma lipids at pre-versus post-equol treatment time points and in vehicle versus equol treatment groups did not identify any significant differences. Despite the lac

SUBMITTER: Eyster K 

PROVIDER: S-EPMC3972297 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature