Vitamin D regulates contractile profile in human uterine myometrial cells via NF-κB pathway.

ABSTRACT:

Objective

Infection triggers inflammation that, in turn, enhances the expression of contractile-associated factors in myometrium and increases the risk of preterm delivery. In this study, we assessed vitamin D regulation of inflammatory markers, contractile-associated factors, steroid hormone receptors, and NFκB pathway proteins in human uterine myometrial smooth muscle (UtSM) cells that were cultured in an inflammatory environment.

Study design

Inflammatory environment was simulated for UtSM cells by coculturing them with monocyte lineage (THP1) cells. We measured the expression of inflammatory markers, contractile-associated factors, steroid hormone receptors, and NFκB pathway proteins in UtSM cells that were cultured with THP1 cells in the presence and absence of vitamin

SUBMITTER: Thota C 

PROVIDER: S-EPMC3972355 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature