Ontology highlight
ABSTRACT:
SUBMITTER: Meng E
PROVIDER: S-EPMC3972499 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Scientific reports 20140402
The voltage-gated sodium channel (VGSC) interacting peptide is of special interest for both basic research and pharmaceutical purposes. In this study, we established a yeast-two-hybrid based strategy to detect the interaction(s) between neurotoxic peptide and the extracellular region of VGSC. Using a previously reported neurotoxin JZTX-III as a model molecule, we demonstrated that the interactions between JZTX-III and the extracellular regions of its target hNav1.5 are detectable and the detecte ...[more]