Propionyl-L-Carnitine is Efficacious in Ulcerative Colitis Through its Action on the Immune Function and Microvasculature.

ABSTRACT:

Objectives

Microvascular endothelial dysfunction characterizes ulcerative colitis (UC), the most widespread form of inflammatory bowel disease. Intestinal mucosal microvessels in UC display aberrant expression of cell adhesion molecules (CAMs) and increased inflammatory cell recruitment. Propionyl-L-carnitine (PLC), an ester of L-carnitine required for the mitochondrial transport of fatty acids, ameliorates propionyl-CoA bioavailability and reduces oxidative stress in ischemic tissues. The present study aimed to document the efficacy of anti-oxidative stress properties of PLC in counteracting intestinal microvascular endothelial dysfunction and inflammation.

Methods

To evaluate the efficacy in vivo, we analyzed the effects in intestinal biopsies of patients with mild-to-mode

SUBMITTER: Scioli MG 

PROVIDER: S-EPMC3972692 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature