SDF1 reduces interneuron leading process branching through dual regulation of actin and microtubules.

ABSTRACT: Normal cerebral cortical function requires a highly ordered balance between projection neurons and interneurons. During development these two neuronal populations migrate from distinct progenitor zones to form the cerebral cortex, with interneurons originating in the more distant ganglionic eminences. Moreover, deficits in interneurons have been linked to a variety of neurodevelopmental disorders underscoring the importance of understanding interneuron development and function. We, and others, have identified SDF1 signaling as one important modulator of interneuron migration speed and leading process branching behavior in mice, although how SDF1 signaling impacts these behaviors remains unknown. We previously found SDF1 inhibited leading process branching while increasing the rate of migra

SUBMITTER: Lysko DE 

PROVIDER: S-EPMC3972721 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature