Association of APOA5 rs662799 and rs3135506 polymorphisms with arterial hypertension in Moroccan patients.

ABSTRACT:

Background

The goal of the study is to investigate the association between the APOA5 polymorphisms and haplotypes with Arterial Hypertension (AHT) in Moroccan patients.

Methods

The study was performed in 283 subjects, 149 patients with AHT and 134 controls. All subjects were genotyped for the APOA5 -1131 T > C (rs662799), 56C > G (rs3135506) and c.553G > T (rs2075291) polymorphisms.

Results

There was a strong association between -1131 T > C and 56C > G polymorphisms with AHT. The -1131 T > C and 56C > G polymorphisms were significantly associated with increased systolic blood pressure (SBP) and triglycerides (TG) levels. There were 4 haplotypes with a frequency higher than 5%, constructed from APOA5 polymorphisms, with the following order: -1131 T > C, 56C > G and c.5

SUBMITTER: Ouatou S 

PROVIDER: S-EPMC3972990 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature