Remodeling of the axon initial segment after focal cortical and white matter stroke.

ABSTRACT:

Background and purpose

Recovery from stroke requires neuroplasticity within surviving adjacent cortex. The axon initial segment (AIS) is the site of action potential initiation and a focal point for tuning of neuronal excitability. Remodeling of the AIS may be important to neuroplasticity after stroke.

Methods

Focal cortical stroke in forelimb motor cortex was induced by photothrombosis and compared with sham controls. White matter stroke was produced through stereotactic injection of a vasoconstrictor together with biotinylated dextran amine to retrogradely label injured cortical neurons. AIS length, morphology and number were measured using immunofluorescence and confocal microscopy 2 weeks after stroke.

Results

Within the peri-infarct cortex and after white matter

SUBMITTER: Hinman JD 

PROVIDER: S-EPMC3973016 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature