Sympathetic activity-associated periodic repolarization dynamics predict mortality following myocardial infarction.

ABSTRACT:

Background

Enhanced sympathetic activity at the ventricular myocardium can destabilize repolarization, increasing the risk of death. Sympathetic activity is known to cluster in low-frequency bursts; therefore, we hypothesized that sympathetic activity induces periodic low-frequency changes of repolarization. We developed a technique to assess the sympathetic effect on repolarization and identified periodic components in the low-frequency spectral range (≤0.1 Hz), which we termed periodic repolarization dynamics (PRD).

Methods

We investigated the physiological properties of PRD in multiple experimental studies, including a swine model of steady-state ventilation (n=7) and human studies involving fixed atrial pacing (n=10), passive head-up tilt testing (n=11), low-intensity ex

SUBMITTER: Rizas KD 

PROVIDER: S-EPMC3973112 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature