Association of single-nucleotide polymorphisms of the tau gene with late-onset Parkinson disease.

ABSTRACT:

Context

The human tau gene, which promotes assembly of neuronal microtubules, has been associated with several rare neurologic diseases that clinically include parkinsonian features. We recently observed linkage in idiopathic Parkinson disease (PD) to a region on chromosome 17q21 that contains the tau gene. These factors make tau a good candidate for investigation as a susceptibility gene for idiopathic PD, the most common form of the disease.

Objective

To investigate whether the tau gene is involved in idiopathic PD.

Design, setting, and participants

Among a sample of 1056 individuals from 235 families selected from 13 clinical centers in the United States and Australia and from a family ascertainment core center, we tested 5 single-nucleotide polymorphisms (SNPs) wi

SUBMITTER: Martin ER 

PROVIDER: S-EPMC3973175 | biostudies-literature | 2001 Nov

REPOSITORIES: biostudies-literature