Harnessing the lysosome-dependent antitumor activity of phenothiazines in human small cell lung cancer.

ABSTRACT: Phenothiazines are a family of heterocyclic compounds whose clinical utility includes treatment of psychiatric disorders as well as chemotherapy-induced emesis. Various studies have demonstrated that these compounds possess cytotoxic activities in tumor cell lines of different origin. However, there is considerable confusion regarding the molecular basis of phenothiazine-induced cell death. Lung cancer (LC) remains one of the most prevalent and deadly malignancies worldwide despite considerable efforts in the development of treatment strategies, especially new targeted therapies. In this work, we evaluated the potential utility of phenothiazines in human LC. We show that phenothiazines as single treatment decreased cell viability and induced cell death preferentially in small cell lung car

SUBMITTER: Zong D 

PROVIDER: S-EPMC3973193 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature