Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer.

ABSTRACT: In prostate cancer, androgen receptor (AR) binding and androgen-responsive gene expression are defined by hormone-independent binding patterns of the pioneer factors FoxA1 and GATA2. Insufficient evidence of the mechanisms by which GATA2 contributes to this process precludes complete understanding of a key determinant of tissue-specific AR activity. Our observations suggest that GATA2 facilitates androgen-responsive gene expression by three distinct modes of action. By occupying novel binding sites within the AR gene locus, GATA2 positively regulates AR expression before and after androgen stimulation. Additionally, GATA2 engages AR target gene enhancers prior to hormone stimulation, producing an active and accessible chromatin environment via recruitment of the histone acetyltransferase p

SUBMITTER: Wu D 

PROVIDER: S-EPMC3973339 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature