Immunologic and genetic markers in patients with idiopathic ocular inflammation and a family history of inflammatory bowel disease.

ABSTRACT:

Purpose

To evaluate the prevalence of immunologic and genetic markers in patients with idiopathic ocular inflammation and a family history of inflammatory bowel disease.

Design

Matched case-control study.

Methods

Patients with a diagnosis of idiopathic ocular inflammation and family history of inflammatory bowel disease who did not have inflammatory bowel disease themselves were identified and matched to control patients with idiopathic ocular inflammation. Serum was evaluated for immunologic markers using Prometheus IBD Serology 7. Genomic DNA was analyzed for single nucleotide polymorphisms (SNP) of the NOD2 gene associated with Crohn disease.

Results

Fifteen patients with idiopathic ocular inflammation and family history of inflammatory bowel disease were ma

SUBMITTER: Abbasian J 

PROVIDER: S-EPMC3973432 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature