Building a phylogenomic pipeline for the eukaryotic tree of life - addressing deep phylogenies with genome-scale data.

ABSTRACT: Background Understanding the evolutionary relationships of all eukaryotes on Earth remains a paramount goal of modern biology, yet analyzing homologous sequences across 1.8 billion years of eukaryotic evolution is challenging. Many existing tools for identifying gene orthologs are inadequate when working with heterogeneous rates of evolution and endosymbiotic/lateral gene transfer. Moreover, genomic-scale sequencing, which was once the domain of large sequencing centers, has advanced to the point where small laboratories can now generate the data needed for phylogenomic studies. This has opened the door for increased taxonomic sampling as individual research groups have the ability to conduct genome-scale projects on their favorite non-model organism. Results Here we present some of the to

SUBMITTER: Grant JR 

PROVIDER: S-EPMC3973741 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature