A mathematical model of metabolism and regulation provides a systems-level view of how Escherichia coli responds to oxygen.

ABSTRACT: The efficient redesign of bacteria for biotechnological purposes, such as biofuel production, waste disposal or specific biocatalytic functions, requires a quantitative systems-level understanding of energy supply, carbon, and redox metabolism. The measurement of transcript levels, metabolite concentrations and metabolic fluxes per se gives an incomplete picture. An appreciation of the interdependencies between the different measurement values is essential for systems-level understanding. Mathematical modeling has the potential to provide a coherent and quantitative description of the interplay between gene expression, metabolite concentrations, and metabolic fluxes. Escherichia coli undergoes major adaptations in central metabolism when the availability of oxygen changes. Thus, an integra

SUBMITTER: Ederer M 

PROVIDER: S-EPMC3973912 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature