The impact of tumor necrosis factor α inhibitors on radiographic progression in ankylosing spondylitis.

ABSTRACT:

Objective

To study the effect of tumor necrosis factor α (TNFα) inhibitors on progressive spinal damage in patients with ankylosing spondylitis (AS).

Methods

All AS patients meeting the modified New York criteria who had been monitored prospectively and had at least 2 sets of spinal radiographs a minimum of 1.5 years apart were included in the study (n=334). The patients received standard therapy, which included nonsteroidal antiinflammatory drugs and TNFα inhibitors. Radiographic severity was assessed by the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS). Patients with a rate of AS progression that was ≥1 mSASSS unit/year were considered progressors. Univariable and multivariable regression analyses were done. Propensity score matching and sensitivity analysis w

SUBMITTER: Haroon N 

PROVIDER: S-EPMC3974160 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature