Genome-wide association study of receptive language ability of 12-year-olds.

ABSTRACT:

Purpose

Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach.

Method

The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores.

Results

No SNP associations met the demanding criterion of g

SUBMITTER: Harlaar N 

PROVIDER: S-EPMC3974169 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature