Association of systemic lupus erythematosus susceptibility genes with IgA nephropathy in a Chinese cohort.

ABSTRACT:

Background and objectives

One hypothesis states that IgA nephropathy (IgAN) is a syndrome with an autoimmune component. Recent studies strongly support the notion of shared genetics between immune-related diseases. This study investigated single-nucleotide polymorphisms (SNPs) reported to be associated with systemic lupus erythematosus (SLE) in a Chinese cohort of patients with IgAN and in controls.

Design, setting, participants, & measurements

This study investigated whether SNP markers that had been reported to be associated with SLE were also associated with IgAN in a Chinese population. The study cohort consisted of 1194 patients with IgAN and 902 controls enrolled in Peking University First Hospital from 1997 to 2008.

Results

Ninety-six SNPs mapping to 60 SLE loc

SUBMITTER: Zhou XJ 

PROVIDER: S-EPMC3974348 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature