Lack of association between apolipoprotein C3 gene polymorphisms and risk of nonalcoholic fatty liver disease in a Chinese Han population.

ABSTRACT:

Aim

To investigate the association between two polymorphisms of apolipoprotein C3 (APOC3) and risk of nonalcoholic fatty liver disease (NAFLD) in a Chinese Han population.

Methods

Genotypes for rs2854116 and rs2854117 in APOC3 and the known rs738409 in patatin-like phospholipase domain-containing protein 3 (PNPLA3) in 390 patients with NAFLD and 409 control subjects were determined by sequencing and polymerase chain reaction analysis. Serum lipid profiles were determined using biochemical methods, and an index of insulin resistance (IR, HOMA-IR), serum APOC3 concentrations and total antioxidant status (TAS) were also assessed.

Results

No significant differences in genotype and allele frequencies of rs2854116 and rs2854117 were found between the NAFLD population and th

SUBMITTER: Niu TH 

PROVIDER: S-EPMC3974535 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature