Comparison of the genome of the oral pathogen Treponema denticola with other spirochete genomes.

ABSTRACT: We present the complete 2,843,201-bp genome sequence of Treponema denticola (ATCC 35405) an oral spirochete associated with periodontal disease. Analysis of the T. denticola genome reveals factors mediating coaggregation, cell signaling, stress protection, and other competitive and cooperative measures, consistent with its pathogenic nature and lifestyle within the mixed-species environment of subgingival dental plaque. Comparisons with previously sequenced spirochete genomes revealed specific factors contributing to differences and similarities in spirochete physiology as well as pathogenic potential. The T. denticola genome is considerably larger in size than the genome of the related syphilis-causing spirochete Treponema pallidum. The differences in gene content appear to be attributabl

SUBMITTER: Seshadri R 

PROVIDER: S-EPMC397461 | biostudies-literature | 2004 Apr

REPOSITORIES: biostudies-literature