High-throughput screening for the identification of new therapeutic options for metastatic pheochromocytoma and paraganglioma.

ABSTRACT: Drug repurposing or repositioning is an important part of drug discovery that has been growing in the last few years for the development of therapeutic options in oncology. We applied this paradigm in a screening of a library of about 3,800 compounds (including FDA-approved drugs and pharmacologically active compounds) employing a model of metastatic pheochromocytoma, the most common tumor of the adrenal medulla in children and adults. The collection of approved drugs was screened in quantitative mode, testing the compounds in compound-titration series (dose-response curves). Analysis of the dose-response screening data facilitated the selection of 50 molecules with potential bioactivity in pheochromocytoma cells. These drugs were classified based on molecular/cellular targets and signalin

SUBMITTER: Giubellino A 

PROVIDER: S-EPMC3974653 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature