CD44 gene polymorphisms and environmental factors on oral cancer susceptibility in Taiwan.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is the fourth leading cause of male cancer death in Taiwan. Exposure to environmental carcinogens is the primary risk factor for developing OSCC. CD44, a well-known tumor marker, plays a crucial role in tumor cell differentiation, invasion, and metastasis. This study investigated CD44 single-nucleotide polymorphisms (SNPs) with environmental risk factors to determine OSCC susceptibility and clinicopathological characteristics.

Methodology/principal findings

Real-time polymerase chain reaction (PCR) was used to analyze 6 SNPs of CD44 in 599 patients with oral cancer and 561 cancer-free controls. We determined that the CD44 rs187115 polymorphism carriers with the genotype AG, GG, or AG+GG were associated with oral cancer susceptib

SUBMITTER: Chou YE 

PROVIDER: S-EPMC3974805 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature