First experimental in vivo model of enhanced dengue disease severity through maternally acquired heterotypic dengue antibodies.

ABSTRACT: Dengue (DEN) represents the most serious arthropod-borne viral disease. DEN clinical manifestations range from mild febrile illness to life-threatening hemorrhage and vascular leakage. Early epidemiological observations reported that infants born to DEN-immune mothers were at greater risk to develop the severe forms of the disease upon infection with any serotype of dengue virus (DENV). From these observations emerged the hypothesis of antibody-dependent enhancement (ADE) of disease severity, whereby maternally acquired anti-DENV antibodies cross-react but fail to neutralize DENV particles, resulting in higher viremia that correlates with increased disease severity. Although in vitro and in vivo experimental set ups have indirectly supported the ADE hypothesis, direct experimental evidence

SUBMITTER: Ng JK 

PROVIDER: S-EPMC3974839 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature