Evolutionary conservation of the eumetazoan gene regulatory landscape.

ABSTRACT: Despite considerable differences in morphology and complexity of body plans among animals, a great part of the gene set is shared among Bilateria and their basally branching sister group, the Cnidaria. This suggests that the common ancestor of eumetazoans already had a highly complex gene repertoire. At present it is therefore unclear how morphological diversification is encoded in the genome. Here we address the possibility that differences in gene regulation could contribute to the large morphological divergence between cnidarians and bilaterians. To this end, we generated the first genome-wide map of gene regulatory elements in a nonbilaterian animal, the sea anemone Nematostella vectensis. Using chromatin immunoprecipitation followed by deep sequencing of five chromatin modifications a

SUBMITTER: Schwaiger M 

PROVIDER: S-EPMC3975063 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature