Replication and fine mapping of asthma-associated loci in individuals of African ancestry.

ABSTRACT: Asthma originates from genetic and environmental factors with about half the risk of disease attributable to heritable causes. Genome-wide association studies, mostly in populations of European ancestry, have identified numerous asthma-associated single nucleotide polymorphisms (SNPs). Studies in populations with diverse ancestries allow both for identification of robust associations that replicate across ethnic groups and for improved resolution of associated loci due to different patterns of linkage disequilibrium between ethnic groups. Here we report on an analysis of 745 African-American subjects with asthma and 3,238 African-American control subjects from the Candidate Gene Association Resource (CARe) Consortium, including analysis of SNPs imputed using 1,000 Genomes reference panels

SUBMITTER: Kantor DB 

PROVIDER: S-EPMC3975655 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature