Electroanatomic remodeling of the left stellate ganglion after myocardial infarction.

ABSTRACT:

Objectives

The purpose of this study was to evaluate the changes of left stellate ganglionic nerve activity (SGNA) and left thoracic vagal nerve activity (VNA) after acute myocardial infarction (MI).

Background

Whether MI results in remodeling of extracardiac nerve activity remains unclear.

Methods

We implanted radiotransmitters to record the SGNA, VNA, and electrocardiogram in 9 ambulatory dogs. After baseline monitoring, MI was created by 1-h balloon occlusion of the coronary arteries. The dogs were then continuously monitored for 2 months. Both stellate ganglia were stained for growth-associated protein 43 and synaptophysin. The stellate ganglia from 5 normal dogs were used as control.

Results

MI increased 24-h integrated SGNA from 7.44 ± 7.19 Ln(Vs)/day at

SUBMITTER: Han S 

PROVIDER: S-EPMC3975658 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature