Integrative analysis of 1q23.3 copy-number gain in metastatic urothelial carcinoma.

ABSTRACT:

Purpose

Metastatic urothelial carcinoma of the bladder is associated with multiple somatic copy-number alterations (SCNAs). We evaluated SCNAs to identify predictors of poor survival in patients with metastatic urothelial carcinoma treated with platinum-based chemotherapy.

Experimental design

We obtained overall survival (OS) and array DNA copy-number data from patients with metastatic urothelial carcinoma in two cohorts. Associations between recurrent SCNAs and OS were determined by a Cox proportional hazard model adjusting for performance status and visceral disease. mRNA expression was evaluated for potential candidate genes by NanoString nCounter to identify transcripts from the region that are associated with copy-number gain. In addition, expression data from an indepe

SUBMITTER: Riester M 

PROVIDER: S-EPMC3975677 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature