Rare nonsynonymous exonic variants in addiction and behavioral disinhibition.

ABSTRACT:

Background

Substance use is heritable, but few common genetic variants have been associated with these behaviors. Rare nonsynonymous exonic variants can now be efficiently genotyped, allowing exome-wide association tests. We identified and tested 111,592 nonsynonymous exonic variants for association with behavioral disinhibition and the use/misuse of nicotine, alcohol, and illicit drugs.

Methods

Comprehensive genotyping of exonic variation combined with single-variant and gene-based tests of association was conducted in 7181 individuals; 172 candidate addiction genes were evaluated in greater detail. We also evaluated the aggregate effects of nonsynonymous variants on these phenotypes using Genome-wide Complex Trait Analysis.

Results

No variant or gene was significant

SUBMITTER: Vrieze SI 

PROVIDER: S-EPMC3975816 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature