Angiotensin type 1 receptor inhibition enhances the extinction of fear memory.

ABSTRACT:

Background

The current effective treatment options for posttraumatic stress disorder (PTSD) are limited, and therefore the need to explore new treatment strategies is critical. Pharmacological inhibition of the renin-angiotensin system is a common approach to treat hypertension, and emerging evidence highlights the importance of this pathway in stress and anxiety. A recent clinical study from our laboratory provides evidence supporting a role for the renin-angiotensin system in the regulation of the stress response in patients diagnosed with PTSD.

Methods

With an animal model of PTSD and the selective angiotensin receptor type 1 (AT1) antagonist losartan, we investigated the acute and long-term effects of AT1 receptor inhibition on fear memory and baseline anxiety. After los

SUBMITTER: Marvar PJ 

PROVIDER: S-EPMC3975818 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature