A pilot study of basal ganglia and thalamus structure by high dimensional mapping in children with Tourette syndrome.

ABSTRACT:

Background

Prior brain imaging and autopsy studies have suggested that structural abnormalities of the basal ganglia (BG) nuclei may be present in Tourette Syndrome (TS). These studies have focused mainly on the volume differences of the BG structures and not their anatomical shapes.  Shape differences of various brain structures have been demonstrated in other neuropsychiatric disorders using large-deformation, high dimensional brain mapping (HDBM-LD).  A previous study of a small sample of adult TS patients demonstrated the validity of the method, but did not find significant differences compared to controls. Since TS usually begins in childhood and adult studies may show structure differences due to adaptations, we hypothesized that differences in BG and thalamus structure geome

SUBMITTER: Williams AC 

PROVIDER: S-EPMC3976104 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature