DNA mismatch repair gene MSH6 implicated in determining age at natural menopause.

ABSTRACT: The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain <15% of the genetic component. We have used genome-wide association in a bivariate meta-analysis of both traits to identify genes involved in determining reproductive lifespan. We observed significant genetic correlation between the two traits using genome-wide complex trait analysis. However, we found no robust statistical evidence for individual variants with an effect on both trai

SUBMITTER: Perry JR 

PROVIDER: S-EPMC3976329 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature